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As I know 3 x a week is still effective I didn't and don't feel the need to increase frequency and risk irritation! Albeit i take it at night because i need to be able to drive to work in the day as it can make you quite sleepy, but im my opinion , worth it. In general, athletes are often managed by their handlers in many areas of what they do! If you fit Canadian defined CFS or the international consensus ME defination? If test stimulation is successful, one can consider permanent device implantation.